Do Aldosterone Synthase Inhibitors reduce blood pressure in hypertensive patients?
Aldosterone synthase inhibitors are a potential treatment option for hypertension that effectively reduce blood pressure but carry an increased risk of hyperkalemia.
ASIs effectively reduce systolic and diastolic blood pressure in hypertensive patients and have a tolerable safety profile. The increased risk of hyperkalemia requires careful monitoring. These findings suggest ASIs are a potential treatment option for hypertension, pending further research in larger studies.
Marzano et al. (2025) studied this question.