To systematically evaluate and quantify the extent and trajectory of weight regain following the cessation of medications prescribed for weight management.
Conducted a systematic review and meta-analysis registered under PROSPERO protocol CRD42024532069.
Identified and synthesized clinical studies evaluating post-treatment weight changes following the discontinuation of weight-loss pharmacotherapies.
Synthesized evidence characterizing the trajectory and magnitude of weight regained following the withdrawal of weight management medications.
Identified post-cessation outcomes to clarify long-term maintenance dynamics associated with discontinued anti-obesity pharmacotherapy.