PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
June 19, 2013JAMA1,297 citationsOpen Access

Seroconversion to Multiple Islet Autoantibodies and Risk of Progression to Diabetes in Children

View Full Paper
AZAnette G. ZieglerMRMarian RewersOSOlli Simell

Key Points

  • Determine the long-term risk of developing clinical type 1 diabetes in at-risk children following seroconversion to multiple islet autoantibodies.
  • Tracked children at risk for type 1 diabetes longitudinally over a 15-year follow-up period.
  • Evaluated the development of multiple islet autoantibody seroconversion and monitored subsequent progression to clinical diabetes.
  • The majority of at-risk children with multiple islet autoantibody seroconversion progressed to clinical type 1 diabetes over 15 years.
  • Identified children positive for multiple autoantibodies as the primary high-risk target group for future preventive intervention trials.

Abstract

The majority of children at risk of type 1 diabetes who had multiple islet autoantibody seroconversion progressed to diabetes over the next 15 years. Future prevention studies should focus on this high-risk population.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Ziegler et al. (2013) studied this question.

synapsesocial.com/papers/69db1c840d8d6ef495a3cd42https://doi.org/10.1001/jama.2013.6285
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reevaluation of Autoantibodies to Islet Cell Membrane in IDDM: Failure to Detect Islet Cell Surface Antibodies Using Human Islet Cells as Substrate1992 · 20 citations
  2. 2Diagnostic criteria for diabetes mellitus and other categories of glucose intolerance: 1997 criteria by the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (ADA), 1998 WHO Consultation criteria, and 1985 WHO criteria1999 · 222 citations
  3. 3IA-2 (Islet Cell Antigen 512) Is the Primary Target of Humoral Autoimmunity Against Type 1 Diabetes-Associated Tyrosine Phosphatase Autoantigens1998 · 82 citations
  4. 4Primary Dietary Intervention Study to Reduce the Risk of Islet Autoimmunity in Children at Increased Risk for Type 1 Diabetes2011 · 219 citations
  5. 5PREDICTING INSULIN-DEPENDENT DIABETES1988 · 262 citations