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April 12, 2026International Endodontic Journal0 citations

Foetal Development and Placental Health in Response to Apical Periodontitis Induced in Pregnant Wistar Rats

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ANAna Carla Thalez Ywabuchi NobumotoTTThaís Verônica Saori TsosuraMMMaria Sara de Lima Coutinho Mattera

Key Points

  • To investigate how apical periodontitis impacts placental health and fetal development in pregnant Wistar rats.
  • Induced apical periodontitis in multiple maternal teeth of pregnant Wistar rats.
  • Monitored changes in placental health and fetal development as the number of affected teeth increased.
  • Conducted comparative assessments to determine the severity of effects.
  • More pronounced alterations were observed in placental health with an increasing number of maternal teeth affected by apical periodontitis.
  • Negative effects on fetal development correlated with the severity of dental health issues during pregnancy.

Abstract

Overall, most alterations were more pronounced with an increasing number of maternal teeth affected by AP, emphasizing the importance of maternal oral health in preventing placental dysfunction and adverse fetal developmental outcomes.

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Cite This Study

Nobumoto et al. (2026) studied this question.

synapsesocial.com/papers/69db37044fe01fead37c4f19https://doi.org/10.1111/iej.70155
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