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April 12, 2026Cornea0 citations

A Multicenter, Randomized, Double-Masked, Sham-Controlled Phase 3 Study to Evaluate the Efficacy and Safety of Epithelium-on Corneal Crosslinking in Keratoconus Subjects 8 to 45 Years of Age: Baseline Endothelial Studies

MBMichael Wellington Belin JDJanet DeMarchi BBBeth Ann Benetz

Key Points

To evaluate the efficacy and safety of epithelium-on corneal crosslinking in individuals with keratoconus.
Conducted a multicenter randomized phase 3 trial
Included subjects aged 8 to 45 with diagnosed keratoconus
Implemented sham-controlled and double-masked study design
Analyzed baseline endothelial studies to assess impact on ECD
As keratoconus severity increases, endothelial cell density (ECD) significantly decreases
Even in advanced keratoconus stages, ECD values remain within a physiological range

Abstract

Increasing keratoconus tomographic severity results in a significant decrease in ECD. However, even in the most advanced stages, the ECD remains within physiological range.

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Cite This Study

Belin et al. (2026) studied this question.

synapsesocial.com/papers/69db380f4fe01fead37c6397 https://doi.org/10.1097/ico.0000000000004160

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April 12, 2026Cornea0 citations

A Multicenter, Randomized, Double-Masked, Sham-Controlled Phase 3 Study to Evaluate the Efficacy and Safety of Epithelium-on Corneal Crosslinking in Keratoconus Subjects 8 to 45 Years of Age: Baseline Endothelial Studies

View Full Paper

MBMichael Wellington Belin JDJanet DeMarchi BBBeth Ann Benetz

Key Points

To evaluate the efficacy and safety of epithelium-on corneal crosslinking in individuals with keratoconus.
Conducted a multicenter randomized phase 3 trial
Included subjects aged 8 to 45 with diagnosed keratoconus
Implemented sham-controlled and double-masked study design
Analyzed baseline endothelial studies to assess impact on ECD
As keratoconus severity increases, endothelial cell density (ECD) significantly decreases
Even in advanced keratoconus stages, ECD values remain within a physiological range

Abstract

Increasing keratoconus tomographic severity results in a significant decrease in ECD. However, even in the most advanced stages, the ECD remains within physiological range.

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Helpful

Bookmark

View Full Paper

Cite This Study

Belin et al. (2026) studied this question.

synapsesocial.com/papers/69db380f4fe01fead37c6397 https://doi.org/10.1097/ico.0000000000004160

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