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April 12, 2026Andrology0 citations

USP2 Attenuates Spermatogenic Cell Apoptosis Via PINK1/Parkin‐Dependent Mitophagy in Varicocoele: A Functional Study

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RYRui‐Jie YaoHXHong XiaoJZJun‐Hang Zheng

Key Points

  • Investigate how USP2 influences spermatogenic cell apoptosis through mitophagy mechanisms in varicocoele.
  • Examined the role of USP2 in mitochondrial quality control
  • Analyzed PINK1/Parkin-mediated autophagy
  • Assessed oxidative stress levels in spermatogenic cells
  • USP2 was found to reduce apoptosis in spermatogenic cells
  • Enhanced mitochondrial function was observed with USP2 activation
  • Potential of USP2 identified as a biomarker and therapeutic target for male infertility

Abstract

Ubiquitin-specific peptidase 2 is essential for maintaining mitochondrial quality control and spermatogenic cell survival in varicocoele by regulating PINK1/Parkin-mediated autophagy and oxidative stress, highlighting its potential as a biomarker and therapeutic target for varicocoele-related male infertility.

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Cite This Study

Yao et al. (2026) studied this question.

synapsesocial.com/papers/69db38274fe01fead37c6543https://doi.org/10.1111/andr.70230
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