Genotype-negative hypertrophic cardiomyopathy may represent a distinct clinical entity where cardiovascular risk factors, particularly hypertension, contribute to disease development.
CVRF, particularly hypertension, are more prevalent in G- patients independent of age, suggesting that cardiovascular health may contribute to HCM disease development. Male-female differences suggest female-specific factors affecting the development of HCM in women. Recognizing G- HCM as a distinct clinical entity may have important implications for patient management, and a more comprehensive understanding of its aetiology may aid in tailoring future therapies.
Schoonvelde et al. (2025) studied this question.
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