Myocardial metabolomic profiling can robustly distinguish between pathological and physiological cardiac remodeling in early-stage heart failure.
Mitochondrial energy metabolic derangements that occur during the early development of pressure overload-induced HF involve both transcriptional and post-transcriptional events. A subset of the myocardial metabolomic profile robustly distinguished pathological and physiological cardiac remodeling.
Lai et al. (2014) studied this question.