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April 13, 2026Cell Biology and Toxicology1 citationsOpen Access

Post-transcriptional activation of TGF-β signaling via SMAD mRNA stabilization by EIF4A3 promotes EMT and metastasis in gastric cancer

YLYujing LiuYZYanhua ZhangWDWenhuan Dou

Key Points

  • The research aims to explore the role of EIF4A3 in regulating TGF-β/SMAD signaling and its effect on gastric cancer metastasis.
  • Identified EIF4A3's role as a regulator in the TGF-β/SMAD pathway
  • Assessed its impact on epithelial-mesenchymal transition (EMT)
  • Analyzed the feedback loop mechanism between EIF4A3 and TGF-β/SMAD signaling
  • EIF4A3 stabilizes SMAD mRNA, enhancing TGF-β signaling activity
  • The interaction facilitates EMT, contributing to increased metastatic potential in gastric cancer
  • EIF4A3 is proposed as a candidate for future diagnostics and therapeutic strategies.

Abstract

Our study identifies EIF4A3 as a critical post-transcriptional regulator and downstream effector of the TGF-β/SMAD pathway. EIF4A3 forms a positive feedback loop with TGF-β/SMAD signaling, thereby reinforcing EMT and promoting metastatic progression in GC. These findings establish EIF4A3 as a novel post-transcriptional amplifier of TGF-β signaling and a promising candidate for diagnostic and therapeutic intervention in metastatic GC.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69dc87ea3afacbeac03ea07bhttps://doi.org/10.1007/s10565-026-10171-6
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