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April 13, 2026Critical Care1 citationsOpen Access

Sliding doors at the bedside: conditional outcomes and moral judgments in end-of-life care

MVMarco VerganoLCLucia CraxìNZNereo Zamperetti

Key Points

  • The aim is to elucidate how value-based judgments influence clinical outcomes in uncertain prognostic situations.
  • Introduced the concept of conditional outcomes to illustrate their role in decision-making.
  • Analyzed a case study of a patient with advanced amyotrophic lateral sclerosis.
  • Examined how differing value interpretations alter clinical framing of patient outcomes.
  • Identified that prognostic determinations can vary based on values rather than biological states.
  • Demonstrated that patient outcomes are co-determined by values espoused by patients, families, and clinicians.
  • Concluded that explicit recognition of value-based judgments enhances shared decision-making and ethical reasoning.

Abstract

Intensive care medicine has increasingly embraced shared decision-making and advance care planning as core components of good clinical practice. Nonetheless, clinical reasoning is sometimes implicitly framed as a linear, biologically driven process. In contexts of prognostic uncertainty, this framing risks obscuring a structural feature of decision-making: the constitutive role of value-based judgments in shaping prognosis and outcomes. This paper introduces the concept of conditional outcomes to clarify a structural feature of certain clinical situations, in which survival or death does not follow from biology alone but is co-determined within the range of biologically possible trajectories by value-based choices made by patients, families, and clinicians regarding whether and how to intervene. Using the case of Mrs. Elizabeth, a woman with advanced amyotrophic lateral sclerosis, we show how an identical clinical state may be framed as either terminal or amenable to escalation, not because it is assessed differently, but because values and goals are interpreted and enacted differently. Even when shared decision-making is practiced, the way value judgments shape prognostic determinations often remains implicit. Making these assumptions explicit complements shared decision-making and advance care planning, clarifying how clinical outcomes are logically dependent on prior value-based commitments that shape judgments about benefit, burden, and the goals of care. Making the conditional structure of outcomes explicit clarifies that value-based judgments are not ancillary to prognosis but structurally shape prognostic determinations and subsequent outcomes. Recognizing the conditional nature of prognostication strengthens clinical reasoning by integrating biological knowledge with ethical commitments in end-of-life care.

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Cite This Study

Vergano et al. (2026) studied this question.

synapsesocial.com/papers/69dc88583afacbeac03ea363https://doi.org/10.1186/s13054-026-05967-1
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