AbstractGingival hyperpigmentation is defined as the darkening or discoloration of the gingiva due to excessive deposition of melanin within the basal and suprabasal layers of the gingival epithelium. Gingival depigmentation is a perio-plastic procedure aimed at restoring a lighter gingival appearance; however, it results in a denuded wound that heals by secondary intention and may lead to postoperative pain and discomfort. Topical medicaments are advocated not only to enhance healing and but also for patient comfort. In this present case report, a 23-yearold female patient with deeply pigmented gingiva underwent gingival depigmentation using a ceramic soft tissue trimmer/bur. Postoperatively, the depigmented surgical site was topically TM applied with REGEN-D® 60 gel on the right side and Hexigel on the left side. Clinical evaluations were conducted on the 3rd, 10th, and 30th postoperative days using the Visual Analogue Scale (VAS) for pain and epithelization tests using hydrogen peroxide and toluidine blue. Both topical agents demonstrated satisfactory healing outcomes and reduction in postoperative discomfort was observed. This case report has shown that REGEN-D® 60 gel has comparatively faster epithelialization, improved angiogenesis, enhanced granulation tissue formation, and greater patient satisfaction.
Shweta Gupta (2026) studied this question.