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May 13, 2008Circulation310 citations

Inhibition of Interleukin-1 by Anakinra Improves Vascular and Left Ventricular Function in Patients With Rheumatoid Arthritis

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IIIgnatios IkonomidisPreventive CardiologyJLJohn LekakisGeneral CardiologyMNMaria NikolaouUniversity of Nicosia

Structured PICO

Does interleukin-1 inhibition by anakinra improve vascular and left ventricular function in patients with rheumatoid arthritis?

P
Population
Patients with Rheumatoid Arthritis
I
Intervention
Anakinra (Interleukin-1 inhibition)
O
Outcome
Vascular and left ventricular functionsurrogate

Anakinra improves vascular and left ventricular function and reduces nitrooxidative stress in patients with rheumatoid arthritis.

Abstract

Interleukin-1 inhibition improves vascular and left ventricular function and is associated with reduction of nitrooxidative stress and endothelin.

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Ikonomidis et al. (2008) studied this question.

synapsesocial.com/papers/69dcb25cc099bcfdbb1332c5https://doi.org/10.1161/circulationaha.107.731877
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