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November 7, 2013American Journal of Respiratory and Critical Care Medicine666 citations

Randomized, Double-Blind, Placebo-controlled Study of Brodalumab, a Human Anti–IL-17 Receptor Monoclonal Antibody, in Moderate to Severe Asthma

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WBWilliam W. BusseSHStephen T. HolgateEKEdward Kerwin

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Abstract

Inhibition of IL-17 receptor A did not produce a treatment effect in subjects with asthma. The results of the high-reversibility subgroup analysis are of uncertain significance, requiring further study of brodalumab in this asthma subpopulation. Clinical trial registered with www.clinicaltrials.gov (NCT01199289).

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Busse et al. (2013) studied this question.

synapsesocial.com/papers/69dcc465a5c75be4cfe54051https://doi.org/10.1164/rccm.201212-2318oc
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