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February 21, 2002New England Journal of Medicine5,434 citationsOpen Access

Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia

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SBStephen BernardTGTimothy W. GrayMBMichael Buist

Key Points

  • This research investigates whether induced moderate hypothermia can enhance recovery in patients with coma following cardiac arrest.
  • Observational analysis of treatment effects in patients after out-of-hospital cardiac arrest.
  • Intervention involved application of moderate hypothermia in comatose individuals post-resuscitation.
  • Induced hypothermia was associated with improved neurological outcomes in patients after cardiac arrest.

Abstract

Our preliminary observations suggest that treatment with moderate hypothermia appears to improve outcomes in patients with coma after resuscitation from out-of-hospital cardiac arrest.

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Cite This Study

Bernard et al. (2002) studied this question.

synapsesocial.com/papers/69dcd5b2c099bcfdbb133e46https://doi.org/10.1056/nejmoa003289
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Randomized Clinical Study of a Calcium-Entry Blocker (Lidoflazine) in the Treatment of Comatose Survivors of Cardiac Arrest1991 · 288 citations
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  3. 3Effects of Hypothermic Metabolic Suppression on Hippocampal Glutamate Concentrations After Transient Global Cerebral Ischemia1994 · 102 citations
  4. 4The effect of profound hypothermia on preservation of cerebral ATP content during circulatory arrest1968 · 182 citations
  5. 5A wilcoxon‐type test for trend1985 · 1,932 citations