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April 1, 2020Circulation Cardiovascular Interventions187 citationsOpen Access

Effects of Acute Colchicine Administration Prior to Percutaneous Coronary Intervention

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BSBinita ShahMPMichael H. PillingerJZJudy Zhong

Key Points

  • The aim is to evaluate the effect of colchicine on inflammatory markers and myocardial injury during PCI.
  • Randomized trial comparing acute colchicine administration to placebo before PCI.

Structured PICO

Does acute preprocedural administration of colchicine reduce inflammation and myocardial injury in patients undergoing PCI?

P
Population
Patients undergoing percutaneous coronary intervention (PCI)
I
Intervention
Acute preprocedural administration of colchicine
C
Comparator
Placebo
O
Outcome
Increase in interleukin-6 and high-sensitivity C-reactive protein concentrations after PCI, and risk of PCI-related myocardial injurysurrogate

Acute preprocedural colchicine reduces post-PCI inflammatory markers but fails to prevent PCI-related myocardial injury.

Abstract

Acute preprocedural administration of colchicine attenuated the increase in interleukin-6 and high-sensitivity C-reactive protein concentrations after PCI when compared with placebo but did not lower the risk of PCI-related myocardial injury. Registration: URL: https://www.clinicaltrials.gov; Unique Identifiers: NCT02594111, NCT01709981.

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Cite This Study

Shah et al. (2020) studied this question.

synapsesocial.com/papers/69dd4a9e8557d5ab8f40ca14https://doi.org/10.1161/circinterventions.119.008717
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