What question did this study set out to answer?

To synthesize and evaluate gadolinium-based nanoscale metal-organic frameworks as multimodal contrast-enhancing agents for optical and magnetic resonance imaging.

June 27, 2006Journal of the American Chemical Society879 citationsOpen Access

Nanoscale Metal−Organic Frameworks as Potential Multimodal Contrast Enhancing Agents

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WRWilliam J. Rieter KTK. Taylor-Pashow HAHongyu An

Key Points

To synthesize and evaluate gadolinium-based nanoscale metal-organic frameworks as multimodal contrast-enhancing agents for optical and magnetic resonance imaging.
Synthesized Gd3+-centered nanoscale metal-organic frameworks (NMOFs) with benzenedicarboxylate and benzenetricarboxylate ligands via reverse microemulsions.
Characterized structural and physical properties using scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), and thermogravimetric analysis (TGA).
Doped frameworks with Eu3+ or Tb3+ centers to assess optical luminescence alongside MRI relaxometry.
NMOFs exhibited extraordinarily high R1 and R2 relaxivities due to the concentration of up to tens of millions of Gd3+ centers per nanoparticle.
Eu3+ and Tb3+ doping imparted strong optical luminescence to the frameworks, confirming dual optical and T1/T2 MRI contrast capabilities.

Abstract

Nanoscale metal-organic frameworks (NMOFs) based on Gd3+ centers and benzenedicarboxylate and benzenetricarboxylate bridging ligands were synthesized using reverse microemulsions and characterized using SEM, PXRD, and TGA. These NMOFs exhibit extraordinarily large R1 and R2 relaxivities because of the presence of up to tens of millions of Gd3+ centers in each nanoparticle and are thus efficient T1 and T2 contrast agents for MRI. The NMOFs can also be made highly luminescent by doping with Eu3+ or Tb3+ centers. The results from this work suggest that NMOFs can be used as potential contrast agents for multimodal imaging.

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Cite This Study

Rieter et al. (2006) studied this question.

synapsesocial.com/papers/69dd4d1127c48be1bb40cbab https://doi.org/10.1021/ja0627444

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June 27, 2006Journal of the American Chemical Society879 citationsOpen Access

Nanoscale Metal−Organic Frameworks as Potential Multimodal Contrast Enhancing Agents

View Full Paper

WRWilliam J. Rieter KTK. Taylor-Pashow HAHongyu An

Key Points

To synthesize and evaluate gadolinium-based nanoscale metal-organic frameworks as multimodal contrast-enhancing agents for optical and magnetic resonance imaging.
Synthesized Gd3+-centered nanoscale metal-organic frameworks (NMOFs) with benzenedicarboxylate and benzenetricarboxylate ligands via reverse microemulsions.
Characterized structural and physical properties using scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), and thermogravimetric analysis (TGA).
Doped frameworks with Eu3+ or Tb3+ centers to assess optical luminescence alongside MRI relaxometry.
NMOFs exhibited extraordinarily high R1 and R2 relaxivities due to the concentration of up to tens of millions of Gd3+ centers per nanoparticle.
Eu3+ and Tb3+ doping imparted strong optical luminescence to the frameworks, confirming dual optical and T1/T2 MRI contrast capabilities.

Abstract

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Cite This Study

Rieter et al. (2006) studied this question.

synapsesocial.com/papers/69dd4d1127c48be1bb40cbab https://doi.org/10.1021/ja0627444

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