Does in vivo DT-CMR characterize myocardial microstructural dynamics in patients with DCM and HCM?
In vivo DT-CMR provides novel noninvasive insights into contractile dysfunction by characterizing abnormal sheetlet function and conformation in DCM and HCM.
Myocardial microstructure dynamics can be characterized by in vivo DT-CMR. Sheetlet function was abnormal in DCM with altered systolic conformation and reduced mobility, contrasting with HCM, which showed reduced mobility with altered diastolic conformation. These novel insights significantly improve understanding of contractile dysfunction at a level of noninvasive interrogation not previously available in humans.
Nielles‐Vallespin et al. (2017) studied this question.