What question did this study set out to answer?

Identify the key genomic and transcriptomic alterations that drive poorly differentiated and anaplastic thyroid cancers to better understand advanced tumor biology.

February 14, 2016Journal of Clinical Investigation1,318 citationsOpen Access

Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers

ILIñigo LandaBrigham and Women's Hospital TITihana IbrahimpašićMemorial Sloan Kettering Cancer Center LBLaura BoucaiMemorial Sloan Kettering Cancer Center

Key Points

Identify the key genomic and transcriptomic alterations that drive poorly differentiated and anaplastic thyroid cancers to better understand advanced tumor biology.
Performed comprehensive genomic and transcriptomic sequencing on tumor samples from patients with poorly differentiated and anaplastic thyroid cancers.
Identified distinct mutational profiles and transcriptional signatures characteristic of poorly differentiated and lethal anaplastic thyroid carcinomas.
Characterized gene expression patterns linked to tumor dedifferentiation, invasiveness, and high-risk disease progression.

Abstract

This work was supported in part by NIH grants CA50706, CA72597, P50-CA72012, P30-CA008748, and 5T32-CA160001; the Lefkovsky Family Foundation; the Society of Memorial Sloan Kettering; the Byrne fund; and Cycle for Survival.

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Cite This Study

Landa et al. (2016) studied this question.

synapsesocial.com/papers/69dd6f3a30fba8aacf40c67d https://doi.org/10.1172/jci85271

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February 14, 2016Journal of Clinical Investigation1,318 citationsOpen Access

Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers

ILIñigo LandaBrigham and Women's Hospital TITihana IbrahimpašićMemorial Sloan Kettering Cancer Center LBLaura BoucaiMemorial Sloan Kettering Cancer Center

Key Points

Identify the key genomic and transcriptomic alterations that drive poorly differentiated and anaplastic thyroid cancers to better understand advanced tumor biology.
Performed comprehensive genomic and transcriptomic sequencing on tumor samples from patients with poorly differentiated and anaplastic thyroid cancers.
Identified distinct mutational profiles and transcriptional signatures characteristic of poorly differentiated and lethal anaplastic thyroid carcinomas.
Characterized gene expression patterns linked to tumor dedifferentiation, invasiveness, and high-risk disease progression.

Abstract

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Cite This Study

Landa et al. (2016) studied this question.

synapsesocial.com/papers/69dd6f3a30fba8aacf40c67d https://doi.org/10.1172/jci85271

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