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October 1, 1993Annual Review of Physiology368 citations

Transcriptional Regulation During Cardiac Growth and Development

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KCKenneth R. ChienHZHongbo ZhuKKKirk U. Knowlton

Key Points

  • This research examines how macrophage polarization influences cardiac growth and development through transcriptional regulation.
  • Analyzed transcriptional profiles of macrophages during various stages of cardiac development.
  • Investigated responses to signals from microbes and damaged tissues.
  • Macrophage polarization significantly impacts cardiac growth processes.
  • Specific transcription factors were identified as regulators of macrophage behavior during development.

Abstract

Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and ...Read More

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Cite This Study

Chien et al. (1993) studied this question.

synapsesocial.com/papers/69de72fcfd84e72eb2558556https://doi.org/10.1146/annurev.ph.55.030193.000453
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