PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
July 1, 2005American Journal of Respiratory and Critical Care Medicine264 citationsOpen Access

NADPH Oxidase Mediates Hypersomnolence and Brain Oxidative Injury in a Murine Model of Sleep Apnea

View Full Paper
GZGuanxia ZhanFSFaridis SerranoPFPolina Fenik

Key Points

Key points are not available for this paper at this time.

Abstract

Collectively, these findings strongly support a critical role for NADPH oxidase in the lasting hypersomnolence and oxidative and proinflammatory responses after hypoxia/reoxygenation patterns simulating severe obstructive sleep apnea oxygenation, highlighting the potential of inhibiting NADPH oxidase to prevent oxidation-mediated morbidities in obstructive sleep apnea.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Zhan et al. (2005) studied this question.

synapsesocial.com/papers/69de9d385e582bd3c5e93e64https://doi.org/10.1164/rccm.200504-581oc
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of CPAP on vigilance and related functions in patients with the sleep apnea/hypopnea syndrome.2000 · 27 citations
  2. 2gp91phox-Containing NADPH Oxidase Mediates Endothelial Dysfunction in Renovascular Hypertension2004 · 254 citations
  3. 3Plasma cytokine levels in patients with obstructive sleep apnea syndrome: a preliminary study2003 · 192 citations
  4. 4Time-course of the expression of inflammatory cytokines and matrix metalloproteinases in the striatum and mesencephalon of mice injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a dopaminergic neurotoxin2003 · 68 citations
  5. 5The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases2003 · 692 citations