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November 12, 2017New England Journal of Medicine778 citationsOpen Access

Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery

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CMC. David MazerRWRichard WhitlockDFDean Fergusson

Key Points

  • The aim is to determine if a restrictive red-cell transfusion strategy is as effective as a liberal strategy in high-risk cardiac surgery patients.
  • Randomized trial with moderate-to-high risk cardiac surgery patients.
  • Comparison of restrictive and liberal red-cell transfusion strategies.
  • Primary outcome includes death, myocardial infarction, stroke, or new renal failure with dialysis.
  • Restrictive strategy showed noninferiority to liberal strategy for composite outcomes.
  • Less blood was transfused with the restrictive strategy.
  • Primary outcomes included death from any cause, myocardial infarction, stroke, or new-onset renal failure with dialysis.

Abstract

In patients undergoing cardiac surgery who were at moderate-to-high risk for death, a restrictive strategy regarding red-cell transfusion was noninferior to a liberal strategy with respect to the composite outcome of death from any cause, myocardial infarction, stroke, or new-onset renal failure with dialysis, with less blood transfused. (Funded by the Canadian Institutes of Health Research and others; TRICS III ClinicalTrials.gov number, NCT02042898 .).

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Cite This Study

Mazer et al. (2017) studied this question.

synapsesocial.com/papers/69debb3f499d77a496b0ca28https://doi.org/10.1056/nejmoa1711818
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