Does adrenalectomy for synchronous versus metachronous adrenal metastasis affect overall survival in patients with NSCLC?
While synchronous adrenal metastases in NSCLC are associated with shorter median overall survival compared to metachronous metastases after adrenalectomy, both groups can achieve long-term survival in about 25% of cases.
For an isolated adrenal metastasis from NSCLC, patients with a synchronous metastasis who underwent adrenalectomy had a shorter median overall survival than those with a metachronous metastasis. However, a durable long-term survival is achieved in approximately 25% in both groups.
Tanvetyanon et al. (2008) studied this question.