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May 28, 2013Organic Letters110 citations

A Mild Chemoselective Ru-Catalyzed Reduction of Alkynes, Ketones, and Nitro Compounds

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TSTobias SchabelUniversity of StuttgartCBChristian BelgerUniversity of StuttgartBPBernd PlietkerTechnische Universität Dresden

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Abstract

The chemoselective reduction of alkyne, ketones, or nitro groups using (Ph3P)3RuCl2 as an inexpensive catalyst and Zn/water as a stoichiometric reductant is reported. Depending on the nature of the additive and the temperature, good chemoselectivities were observed allowing, e.g., for the selective reduction of a nitro group in the presence of a ketone or an alkyne.

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Schabel et al. (2013) studied this question.

synapsesocial.com/papers/69df237fd5404a0bea59221dhttps://doi.org/10.1021/ol401185t
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