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January 19, 2017Molecular Cancer217 citationsOpen Access

Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation

AAAbdullah Al‐DhfyanAAAli AlhoshaniHKHesham M. Korashy

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Abstract

The present study provides the first evidence that AhR/CYP1A1 signaling pathway is controlling breast CSCs proliferation, development, self-renewal and chemoresistance through inhibition of the PTEN and activation of β-Catenin and Akt pathways.

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Al‐Dhfyan et al. (2017) studied this question.

synapsesocial.com/papers/69df23ac3b0ba53fb37a181ahttps://doi.org/10.1186/s12943-016-0570-y
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