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April 15, 2026CureusOpen Access

Assessment of Early Antibiotic Administration for Patients With Sepsis in the Emergency Department: A Retrospective Observational Study at a Tertiary Care Hospital

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Authors

ATAbin ThomasSPSreehitha E PVUVishnu C Unnikrishnan

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Overview

Retrospective observational study evaluates early antibiotic impact on mortality in sepsis patients, indicating urgent treatment need.

Key Points

  • To evaluate the timing of antibiotic administration in sepsis patients and its association with in-hospital mortality.
  • Retrospective observational study of 95 patients with sepsis and septic shock.
  • Data collection from electronic medical records including demographics, clinical parameters, and time to antibiotic administration.
  • Statistical analysis using Pearson's chi-square test with p-value < 0.05 considered significant.
  • 68.4% of patients had sepsis without septic shock, and 31.6% had septic shock.
  • 67% of septic shock patients received antibiotics within 60 minutes.
  • Increased mortality associated with delayed antibiotic treatment was statistically significant (χ²= 11.26, p=0.04).
  • Similar trends in mortality were observed across both septic shock and non-shock groups.

Cite This Study

Thomas et al. (2026) studied this question.

synapsesocial.com/papers/69df2a99e4eeef8a2a6af930https://doi.org/10.7759/cureus.106896
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