Pre-Engraftment Syndrome After Autologous Stem Cell Transplantation in Relapsed or Refractory Hodgkin Lymphoma: An Association with Prior PD-1 Inhibitor Exposure
Retrospective cohort study evaluates pre-engraftment syndrome in Hodgkin lymphoma post-transplantation, suggesting implications for corticosteroid use.
Key Points
The aim is to evaluate inflammatory events before neutrophil recovery after autologous stem cell transplantation in Hodgkin lymphoma patients, focusing on pre-engraftment syndrome.
Retrospective cohort study of 64 adult patients with Hodgkin lymphoma undergoing autologous stem cell transplantation.
Assessment of pre-engraftment syndrome based on Spitzer and Maiolino criteria.
Comparison of clinical and laboratory parameters using non-parametric statistical analyses.
No patients met the Spitzer criteria for classical engraftment syndrome.
34 patients (53.1%) exhibited pre-engraftment syndrome when disregarding the conventional engraftment time frame.
All clinically significant pre-engagement syndrome cases requiring steroids occurred in patients exposed to PD-1 inhibitors.