Does GLP-1 receptor agonists affect the risk of suicidality in patients with type 2 diabetes?
GLP-1 receptor agonists do not appear to increase the risk of suicidality in patients with type 2 diabetes compared to other glucose-lowering medications.
In this large cohort study, the use of GLP-1 receptor agonists was not associated with an increased risk of suicidality compared with the use of DPP-4 inhibitors or SGLT-2 inhibitors in patients with type 2 diabetes.
Shapiro et al. (2025) studied this question.