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January 13, 2011Cardiovascular Research60 citationsOpen Access

Activation of the aryl hydrocarbon receptor by doxorubicin mediates cytoprotective effects in the heart

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MVMaria VolkovaMPMonica PalmeriKRKerry S. Russell

Structured PICO

P
Population
Heart (preclinical model)
I
Intervention
Aryl hydrocarbon receptor (AhR) activation by doxorubicin (DOX)
O
Outcome
DOX metabolism and cardioprotection against DOX-induced cardiotoxicity

Activation of the aryl hydrocarbon receptor mediates cytoprotective effects against doxorubicin-induced cardiotoxicity.

Abstract

These findings indicate that AhR plays an important role in DOX metabolism by the heart and further demonstrate that AhR is cardioprotective against DOX-induced cardiotoxicity.

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Cite This Study

Volkova et al. (2011) studied this question.

synapsesocial.com/papers/69dff587ca6b6a2615860508https://doi.org/10.1093/cvr/cvr007
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