What question did this study set out to answer?

To investigate the relationship between pravastatin use and the onset of breathlessness and antibodies in a patient.

April 16, 2026Breathe0 citationsOpen Access

A case of breathlessness and unexpected antibodies: stating the obvious

IDIlias E. Dimeas GPG PerlepeUniversity of Thessaly PKP Kirgou

Key Points

To investigate the relationship between pravastatin use and the onset of breathlessness and antibodies in a patient.
Case report of a patient with breathlessness after starting pravastatin.
Assessment of antibodies and interstitial changes was conducted.
Statin withdrawal was performed as an intervention to evaluate recovery.
The patient showed transient positivity for anti-HMGCR antibodies.
Breathlessness improved fully after stopping pravastatin.
Findings underscore the need for careful drug causality assessment in interstitial lung disease.

Abstract

Shareable abstract A patient developed breathlessness after starting pravastatin, with transient anti-HMGCR positivity and interstitial changes. Statin withdrawal led to full recovery, highlighting the importance of drug causality assessment in ILD. https://bit.ly/4rdPDZl

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Cite This Study

Dimeas et al. (2026) studied this question.

synapsesocial.com/papers/69e07d1d2f7e8953b7cbe24e https://doi.org/10.1183/20734735.0358-2025

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April 16, 2026Breathe0 citationsOpen Access

A case of breathlessness and unexpected antibodies: stating the obvious

View Full Paper

IDIlias E. Dimeas GPG PerlepeUniversity of Thessaly PKP Kirgou

Key Points

To investigate the relationship between pravastatin use and the onset of breathlessness and antibodies in a patient.
Case report of a patient with breathlessness after starting pravastatin.
Assessment of antibodies and interstitial changes was conducted.
Statin withdrawal was performed as an intervention to evaluate recovery.
The patient showed transient positivity for anti-HMGCR antibodies.
Breathlessness improved fully after stopping pravastatin.
Findings underscore the need for careful drug causality assessment in interstitial lung disease.

Abstract

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Cite This Study

Dimeas et al. (2026) studied this question.

synapsesocial.com/papers/69e07d1d2f7e8953b7cbe24e https://doi.org/10.1183/20734735.0358-2025

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