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February 12, 2025Mini-Reviews in Medicinal Chemistry11 citations

The Role of Renin-Angiotensin System in Diabetic Nephropathy: An Update

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ASAndré SanglardBMBárbara Castello Branco MirandaAVAna Luiza França Vieira

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Abstract

While ACE inhibitors, ARBs, and SGLT2 inhibitors remain central to DN management, the ACE2-Ang-(1-7)-Mas axis presents a promising therapeutic target. Future research should focus on translating preclinical findings into clinical applications, potentially improving DN treatment.

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Cite This Study

Sanglard et al. (2025) studied this question.

synapsesocial.com/papers/69e07e47a4fa27a561459180https://doi.org/10.2174/0113895575344980250130062547
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epigenetics in the pathogenesis of diabetic nephropathy2021 · 135 citations
  2. 2Plasma Angiotensins in Anephric Humans1991 · 30 citations
  3. 3Improved Survival and Renal Prognosis of Patients With Type 2 Diabetes and Nephropathy With Improved Control of Risk Factors2014 · 86 citations
  4. 4Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas2003 · 1,816 citations
  5. 5ACE and ACE2 Activity in Diabetic Mice2006 · 339 citations