IV thrombolysis with tenecteplase is associated with worse 90-day functional outcomes compared to standard of care in patients >80 years with minor stroke and visible occlusion.
Does IV thrombolysis with tenecteplase improve functional outcomes at 90 days in patients >80 years with minor stroke and visible occlusion or perfusion lesion?
In patients over 80 years old with minor ischemic stroke, IV tenecteplase is associated with worse functional outcomes at 90 days compared to standard of care.
This study provides Class III evidence that in patients >80 years with minor stroke and visible occlusion or perfusion lesion, IV thrombolysis with tenecteplase is associated with worse functional outcomes at 90 days compared with nonthrombolytic standard of care therapies.
Ganesh et al. (2026) studied this question. IV thrombolysis with tenecteplase is associated with worse 90-day functional outcomes compared to standard of care in patients >80 years with minor stroke and visible occlusion.