When the Liver Loops Back: Enterohepatic Circulation and Smart Drug Dosing.

Key Points

• The aim is to understand how enterohepatic circulation affects drug behavior and dosing outcomes.
• Analyzed delay-aware models for enterohepatic drugs.
• Examined pharmacokinetic behavior influenced by liver processes.
• Investigated implications for drug dosing strategies.
• Identified unpredictability in drug behavior due to enterohepatic circulation.
• Highlighted the role of delay-aware models in improving dosing accuracy.