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April 17, 2026Advances in Therapy0 citationsOpen Access

Adverse Childhood Experiences and Disease Activity Are Associated with Post-Traumatic Stress Symptoms in Crohn’s Disease

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GSGiorgia SpagnoloDFDaniele FerrareseFVFederica Di Vincenzo

Key Points

  • The research aims to explore the relationship between early-life adversity and post-traumatic stress symptoms in individuals with Crohn's disease.
  • Conducted an observational analysis to assess psychological effects of adverse childhood experiences.
  • Evaluated disease activity in patients with Crohn's disease.
  • Used ACE-informed assessments to identify patients at higher psychological risk.
  • Found a significant association between adverse childhood experiences and increased post-traumatic stress symptoms.
  • Identified disease activity as a contributing factor in this relationship.

Abstract

Early-life adversity appears to increase vulnerability to PTSS in the context of active CD. ACE-informed assessments may help identify patients at higher psychological risk and guide trauma-informed clinical care.

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Cite This Study

Spagnolo et al. (2026) studied this question.

synapsesocial.com/papers/69e1d0715cdc762e9d859327https://doi.org/10.1007/s12325-026-03587-3
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