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April 18, 2026Biomaterials Science0 citationsOpen Access

A click-crosslinked dopamine-functionalized hydrogel for therapeutic delivery of stem cell-derived extracellular vesicles

JCJoshua S. CopusJPJi Hoon ParkAAAnthony Atala

Key Points

  • The aim is to investigate the use of a dopamine-functionalized hydrogel for the delivery of extracellular vesicles to enhance tissue regeneration.
  • Developed a dopamine-functionalized hyaluronic acid hydrogel (Dopa-HA) using click-crosslinking techniques.
  • Assessed the hydrogel's ability to sustain and localize the delivery of extracellular vesicles.
  • Evaluated the effectiveness of Dopa-HA in promoting tissue regeneration.
  • Dopa-HA provided sustained release of extracellular vesicles over time.
  • The hydrogel demonstrated effectiveness in supporting tissue regeneration processes.

Abstract

A click-crosslinked dopamine-functionalized hyaluronic acid hydrogel system (Dopa-HA) provides sustained and localized delivery of bioactive molecules, such as extracellular vesicles (EVs), for in situ tissue regeneration.

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Cite This Study

Copus et al. (2026) studied this question.

synapsesocial.com/papers/69e31ff140886becb653f183https://doi.org/10.1039/d5bm01730k
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