Leukocytoclastic vasculitis (LCV) is histopathologic description of a common form of small vessel vasculitis. This report discusses a unique and novel case of LCV in a 40-year-old white male patient who presented to dermatology with sudden onset of a rash, edema, and mild discomfort affecting his lower extremities suspected to be induced by the glucagon-like peptide-1 (GLP-1) agonist, semaglutide. We review the patient’s presentation, diagnosis through punch biopsy, histopathology, treatment plan, and examine the current literature on GLP-1 agonists inducing cutaneous adverse reactions. This case, which is the third reported in the literature, intends to inform clinicians specializing in dermatology of the potential cutaneous adverse effects of GLP-1 agonists, including LCV.
Harrison et al. (2026) studied this question.