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April 18, 2026Nanomedicine0 citations

A multifunctional lipid-lowering nanotherapeutic alleviates lipid deposition associated microglial dysfunction

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JXJiyao XieYLYining LiuJXJiamei Xie

Key Points

  • This research aims to explore a nanotherapeutic approach to reduce lipid-related dysfunction in microglia.
  • Utilized a multifunctional nanotherapeutic integrating lipid adsorption and berberine loading.
  • Assessed oxidative stress levels in microglia pre- and post-treatment.
  • Compared mitochondrial function in microglia with and without the nanotherapeutic.
  • Demonstrated decreased oxidative stress in treated microglia.
  • Showed reduction in mitochondrial injury associated with lipid overload.
  • Highlighted improved microglial viability in lipid-laden environments after treatment.

Abstract

PB integrates mesoporous lipid adsorption, intrinsic redox buffering, and berberine loading, thereby attenuating oxidative stress and mitochondrial injury associated with lipid overload in microglia. This work highlights the potential of lipid-lowering nanotherapeutic strategies for intervening in lipid-overload-associated microglial dysfunction.

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Cite This Study

Xie et al. (2026) studied this question.

synapsesocial.com/papers/69e3209340886becb653fb4fhttps://doi.org/10.1080/17435889.2026.2658587
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