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April 18, 2026Otolaryngology0 citationsOpen Access

Mucosal Margin Shrinkage in Oral Cavity Cancer: A Systematic Review

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SSS. SridharDLDaniel P. LarsonMTMichael C. Topf

Key Points

  • To investigate the shrinkage of oral cavity tissue following surgical resection and formalin fixation.
  • Conducted a systematic review of existing literature on tissue shrinkage in oral cavity cancer.
  • Analyzed the timing and extent of shrinkage post-surgery and after fixation.
  • Evaluated implications for surgical margin planning.
  • Significant shrinkage noted immediately after surgical resection.
  • Shrinkage also occurs during formalin fixation, impacting tissue size.
  • Understanding shrinkage can improve surgical margin accuracy.

Abstract

Oral cavity tissue undergoes shrinkage both after surgical resection and after fixation with formalin, with the most significant shrinkage occurring immediately after resection. Tissue shrinkage should be an important consideration in the planning of surgical margins.

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Cite This Study

Sridhar et al. (2026) studied this question.

synapsesocial.com/papers/69e320e740886becb6540173https://doi.org/10.1002/ohn.70244
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