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April 18, 2026Reaction Chemistry & Engineering0 citations

Selective Synthesis of Secondary Imines via Reductive Coupling of Aldehydes with Ammonia over Encapsulated NiFe Alloy Catalysts

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YLYulong LeiJLJianguo Liu

Key Points

  • This research aims to develop a method for the selective synthesis of secondary imines using aldehydes and ammonia.
  • Utilized encapsulated NiFe alloy catalysts for the reaction.
  • Performed reductive coupling under specific conditions.
  • Analyzed the formation of secondary imines from various aldehydes.
  • Successfully synthesized secondary imines with high selectivity.
  • Achieved efficient reactions under reductive conditions.
  • Demonstrated the broad applicability of the approach to different aldehyde substrates.

Abstract

Secondary imines (Schiff bases) are versatile intermediates in organic synthesis and pharmaceutical manufacturing.However, their selective synthesis directly from aldehydes and ammonia under reductive conditions is challenging, as the imine functionality...

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Cite This Study

Lei et al. (2026) studied this question.

synapsesocial.com/papers/69e320e740886becb654017fhttps://doi.org/10.1039/d6re00063k
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