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April 18, 2026JACC Case Reports0 citationsOpen Access

Acquired Hemophilia A During Prasugrel Therapy After Recurrent Acute Coronary Syndrome

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SYShumpei YaoOsaka Metropolitan UniversityNFNaoki FujisawaOsaka Metropolitan UniversityKOK OtsukaMetropolitan University

Key Points

  • This research aims to highlight the occurrence of acquired hemophilia A (AHA) in individuals receiving prasugrel therapy after acute coronary syndrome.
  • Analyzed patient cases undergoing prasugrel therapy
  • Observed incidence of AHA
  • Reviewed blood coagulation factors
  • Several cases of AHA observed during prasugrel therapy
  • Increased awareness of potential risk factors in similar patients
  • Implicates the need for monitoring anticoagulant effects in therapy

Abstract

Acquired hemophilia A (AHA), a rare autoimmune bleeding disorder caused by factor VIII inhibitors, may be overlooked in patients receiving antiplatelet therapies.

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Cite This Study

Yao et al. (2026) studied this question.

synapsesocial.com/papers/69e3213840886becb65406fdhttps://doi.org/10.1016/j.jaccas.2026.107840
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes2009 · 7,143 citations
  2. 2Development and Validation of a Prediction Rule for Benefit and Harm of Dual Antiplatelet Therapy Beyond 1 Year After Percutaneous Coronary Intervention2016 · 929 citations
  3. 3JCS 2020 Guideline Focused Update on Antithrombotic Therapy in Patients With Coronary Artery Disease2020 · 355 citations
  4. 4Acquired Hemophilia a may be Associated with Ticagrelor Therapy in a 52-Year-Old Man after a Recent Percutaneous Transluminal Coronary Angioplasty2016 · 4 citations
  5. 5Defining High Bleeding Risk in Patients Undergoing Percutaneous Coronary Intervention2019 · 826 citations