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April 18, 2026EndocrinologyOpen Access

Testosterone protects from metabolic syndrome-associated lung dysfunction in a high-fat diet rabbit model

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Authors

GGGiulia GuarnieriPCPaolo ComeglioSFS Filippi

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Overview

Examines testosterone therapy’s effects on lung function in rabbits with metabolic syndrome, suggesting a potential treatment strategy.

Key Points

  • The study aims to explore how metabolic syndrome affects lung function and the potential protective role of testosterone therapy.
  • Used a high-fat diet rabbit model to induce metabolic syndrome.
  • Evaluated lung function metrics like airway opening pressure.
  • Analyzed tissue for macrophage presence, fibrosis, and inflammatory gene expression.
  • Compared different diet and treatment groups including testosterone administration.
  • Metabolic syndrome led to decreased lung compliance and increased airway pressure.
  • Testosterone therapy improved liver function and reduced inflammation and fibrosis.
  • Hormone levels correlated inversely with airway pressure, indicating lower testosterone predicted lung dysfunction.

Cite This Study

Guarnieri et al. (2026) studied this question.

synapsesocial.com/papers/69e3216540886becb65409dahttps://doi.org/10.1210/endocr/bqag048
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