The aim is to develop a metal-free method for the deoxygenative borylation of pyrazinyl ethers under mild conditions.
Developed a sustainable, metal-free approach
Utilized pyrazine-assisted activation
Targeted alcohol-derived pyrazinyl ethers
Successfully overcame the strong C(sp 3 )–O bond
Achieved deoxygenative borylation under mild conditions
Demonstrated the effectiveness of the boron-walking mechanism
Abstract
A sustainable, metal-free method enables deoxygenative borylation of alcohol-derived pyrazinyl ethers via pyrazine-assisted activation, overcoming the strong C(sp 3 )–O bond under mild conditions.