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April 19, 2026International Journal of Infectious Diseases0 citationsOpen Access

Sporadic Creutzfeldt–Jakob disease presenting with cerebral atrophy following traumatic brain injury mimicking hydrocephalus: a case report

CZChun ZengDGDezhu GaoLWLiang Wu

Key Points

  • To discuss the presentation of sporadic Creutzfeldt–Jakob disease (sCJD) in a patient following a traumatic brain injury.
  • Presented a single case of sCJD with cerebral atrophy after traumatic brain injury.
  • Used MRI imaging to assess cerebral cortex changes.
  • Highlighted differential diagnosis between sCJD and hydrocephalus.
  • Observed rapid progression of dementia symptoms in the patient.
  • MRI showed hyperintensity in the cerebral cortex, indicative of sCJD.
  • Correct diagnosis prevented unnecessary surgical intervention for hydrocephalus.

Abstract

Rapidly progressive dementia is the core symptom of sCJD. Hyperintensity in the cerebral cortex on MRI is a key imaging feature of sCJD. Differentiating sCJD from hydrocephalus prevents unnecessary surgery.

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Cite This Study

Zeng et al. (2026) studied this question.

synapsesocial.com/papers/69e471c5010ef96374d8e09fhttps://doi.org/10.1016/j.ijid.2026.108710
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