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April 19, 2026European Journal of Immunology0 citations

EXPRESSION OF CONCERN: Activation of Epstein‐Barr Virus/C3d Receptor (gp140, CR2, CD21) on Human Cell Surface Triggers pp60src and Akt‐GSK3 Activities Upstream and Downstream to PI 3‐Kinase, Respectively

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Key Points

  • To address data integrity concerns regarding signaling activities triggered by Epstein-Barr virus/C3d receptor activation.
  • Identification of duplicated bands in presented figures
  • Analysis of signaling activities related to gp140, CR2, and CD21
  • Collaboration with journal editors to evaluate the situation
  • Expression of concern highlights potential issues in data validity
  • Authors unable to provide supporting raw data due to elapsed time
  • Journal suggests conclusions may still remain unaffected despite concerns

Abstract

M. Barel, M. Balbo, M. Le Romancer and R. Frade, "Activation of Epstein-Barr Virus/C3d Receptor (gp140, CR2, CD21) on Human Cell Surface Triggers pp60src and Akt-GSK3 Activities Upstream and Downstream to PI 3-Kinase, Respectively," European Journal of Immunology 33, no. 9 (2003): 2557-2566, https://doi.org/10.1002/eji.200324059. This Expression of Concern is for the above article, published online on 18 August 2003 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editors-in-Chief, Matteo Iannacone and Nadja Bakocevic, and Wiley-VCH GmbH, Weinheim. The Expression of Concern has been issued after duplicated bands were identified between the anti‑nucleolin panels presented in Figures 1A2 and 3C2. Due to the time elapsed since publication, the authors were unable to provide supporting raw data. While the journal considers it unlikely that the conclusions of the article are affected, this Expression of Concern is published to inform readers of the issue.

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Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/69e47250010ef96374d8e608https://doi.org/10.1002/eji.70187
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