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April 19, 2026Histopathology0 citations

TERT promoter–mutated thyroid carcinomas: prognostic and histologic insights according to the WHO 2022 classification

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SLSeung Eun LeeBHBogyeong HanJKJung‐Sun Kim

Key Points

  • This research aims to explore the twofold significance of TERT promoter mutations in thyroid carcinomas, focusing on their morphological diversity and prognostic implications.
  • Analyzed histologic features of TERT promoter-mutated thyroid carcinomas.
  • Compared findings with the WHO 2022 classification.
  • Assessed implications for risk stratification.
  • Expanded recognition of morphologic characteristics associated with TERT mutations.
  • Demonstrated the need for routine evaluation of these features in thyroid carcinoma assessments.
  • Highlighted the potential for improved identification of aggressive tumors.

Abstract

Our study provides valuable insights into TERT promoter-mutated TCs, broadening their recognized morphologic spectrum and highlighting the importance of incorporating such features into routine evaluation to improve risk stratification and better identify aggressive tumours.

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Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/69e472fc010ef96374d8ed62https://doi.org/10.1111/his.70152
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