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April 19, 2026Cancer Research0 citations

Abstract LB162: Twistcgp pipeline: A portable, open-source workflow for comprehensive genomic profiling in translational oncology

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NHNils HomerEMErin McAuleyZNZach Norgaard

Key Points

  • The study aims to present a portable, open-source workflow for comprehensive genomic profiling to enhance reproducibility and adaptability in cancer research.
  • Developed the twistcgp bioinformatics workflow based on the Twist Oncology DNA CGP Panel.
  • Implemented the workflow using Nextflow for flexible deployment on various computing platforms.
  • Conducted analyses including somatic SNV detection, copy number variant analysis, TMB estimation, and MSI classification.
  • The workflow successfully detected expected somatic variations with standardized quality metrics across samples.
  • TMB and MSI estimates were consistent with prior expectations based on panel data.
  • The system supports cross-sample and cross-site comparison without reliance on proprietary software.

Abstract

Abstract Comprehensive genomic profiling (CGP) panels are widely used in translational studies Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts) ; 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86 (8Suppl): Abstract nr LB162.

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Cite This Study

Homer et al. (2026) studied this question.

synapsesocial.com/papers/69e4734c010ef96374d8f26ehttps://doi.org/10.1158/1538-7445.am2026-lb162
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