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April 19, 2026Drug Design Development and Therapy0 citationsOpen Access

Dexmedetomidine Plus Stellate Ganglion Block Improves Postoperative Sleep Quality in Elderly Hip Arthroplasty Patients: A Randomized Controlled Trial

YGYanXia GuoSWSha WangMLMaoyun Luo

Key Points

  • The study aims to evaluate the impact of dexmedetomidine combined with stellate ganglion block on postoperative sleep quality in elderly hip arthroplasty patients.
  • Conducted a randomized controlled trial with 126 patients aged ≥ 65 years undergoing hip arthroplasty.
  • Allocated patients into three groups: control (C), dexmedetomidine (D), and dexmedetomidine plus SGB (DS).
  • Administered dexmedetomidine infusion and SGB with ropivacaine for participants in the DS group.
  • Assessed sleep quality using the Richards-Campbell Sleep Questionnaire on the first three postoperative nights.
  • RCSQ scores were significantly higher in Groups D and DS compared to Group C on the first three postoperative nights (P < 0.001).
  • Group D exhibited significantly lower RCSQ scores than Group DS at each postoperative time point (POD 1, 2, and 3, P < 0.001).
  • Group DS reported significantly lower VAS scores on POD 1 and POD 2 compared to Groups D and C (P < 0.001).
  • No significant differences in PSQI scores among the three groups at one month postoperatively (P > 0.05).

Abstract

Purpose: To investigate the effect of dexmedetomidine combined with stellate ganglion block (SGB) on postoperative sleep quality in elderly patients undergoing hip arthroplasty. Methods: 126 patients aged ≥ 65 years undergoing hip arthroplasty were allocated to three groups: control (Group C), dexmedetomidine (Group D), and dexmedetomidine plus SGB (Group DS). Group D received dexmedetomidine (loading dose 0.5μg/kg over 10 min, then 0.2μg/kg/h infusion until surgery end). Group DS received the same regimen plus SGB at C6 with 5mL of 0.375% ropivacaine. The primary outcome was postoperative sleep quality assessed by the Richards-Campbell Sleep Questionnaire (RCSQ) on the first three postoperative nights. Secondary outcomes included postoperative visual analogue scale (VAS) scores, number of patient-controlled analgesia (PCA) and sleep quality using Pittsburgh Sleep Quality Index (PSQI) scores at one month postoperatively. Results: On the first three postoperative nights (POD 1– 3), the RCSQ scores were significantly higher in Groups D and DS compared with Group C ( P 0.05). Conclusion: In elderly patients undergoing hip arthroplasty, dexmedetomidine combined with SGB significantly improved subjective sleep quality during the first three postoperative nights, although this beneficial effect was not maintained at one month postoperatively. Keywords: dexmedetomidine, stellate ganglion block, sleep quality, hip arthroplasty

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Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/69e47376010ef96374d8f36bhttps://doi.org/10.2147/dddt.s587952
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