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April 19, 20260 citationsOpen Access

Oncogenesis as a Regression to Prebiotic Vesicle Dynamics: A Physics Perspective Far from Equilibrium

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PMPeter Mikuláš

Key Points

  • The study aims to explore an alternative perspective on cancer, viewing it through the lens of physical processes rather than solely genetic mutations.
  • Examined existing theories of oncogenesis and non-linear thermodynamics.
  • Referenced experimental models of protocells to support the new model.
  • Proposed a framework for understanding the energy dynamics in cancer cells.
  • Identified cancer cells reverting to primitive behavior similar to early prebiotic systems.
  • Demonstrated that energetic exhaustion leads to a loss of complex biological processes in cancer.
  • Provided a theoretical basis supporting the idea of oncogenesis as a physical bifurcation.

Abstract

Current oncology is dominantly focused on biochemical and genetic reductionism, interpreting cancer as an accumulation of DNA mutations. This paper presents an alternative model that views the oncogenic process as a physical bifurcation. According to the laws of non-linear thermodynamics (I. Prigogine) and experimental models of protocells (J. Szostak), the cancer cell appears to be a system that, due to energetic exhaustion, abandons complex biological regulation and reverts to a primitive, physically driven vesicular aggression characteristic of the prebiotic era.

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Cite This Study

Peter Mikuláš (2026) studied this question.

synapsesocial.com/papers/69e47440010ef96374d90016https://doi.org/10.5281/zenodo.19633298
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