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April 19, 2026JHLT Open0 citationsOpen Access

The Role of Continuous in situ Targeted Antimicrobials in the Successful Treatment of Extensively-drug Resistant Pseudomonas aeruginosa Left Ventricular Assist Device Driveline Infection – A Case Report

WLWei-Ting LinCFChiung-Ta FanCHC Huang

Key Points

  • The aim is to explore the effectiveness of continuous in situ targeted antimicrobials in treating LVAD driveline infections caused by drug-resistant bacteria.
  • Reported a case of LVAD infection due to extensively drug-resistant Pseudomonas aeruginosa.
  • Used systemic antimicrobials combined with CITA and surgical interventions.
  • Monitored infection recurrence and response to treatment.
  • Achieved successful cure of the recurrent LVAD infection.
  • CITA demonstrated effectiveness against biofilm-producing bacteria.
  • Highlighted the importance of combined therapeutic strategies for managing complex infections.

Abstract

Left ventricular assist device (LVAD) driveline infections (DLIs) are common complications (1) and frequently recur despite definite treatment due to bacterial entry and biofilm formation.We report the first case of recurrent, extensively drug-resistant Pseudomonas aeruginosa LVAD infection successfully cured using systemic antimicrobials, continuous in-situ targeted antibiotics (CITA), and repeated surgical interventions, highlighting CITA's therapeutic potential.

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Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/69e47440010ef96374d9004fhttps://doi.org/10.1016/j.jhlto.2026.100570
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