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April 19, 2026Skin Health and DiseaseOpen Access

Association between prescribed antidepressant medication and skin cancer (melanoma, basal cell carcinoma and cutaneous squamous cell carcinoma) risk: a systematic review and meta-analysis

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Authors

TRTabassum RahmanMSMikolaj SwiderskiZVZoe C Venables

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Overview

Systematic review assesses antidepressant impact on skin cancer risk, indicating no significant association.

Key Points

  • This research aims to examine the link between prescribed antidepressants and the risk of various skin cancers.
  • Literature search conducted on MEDLINE and Embase.
  • Ten studies were selected for review and five were included in the meta-analysis.
  • Odds ratios and rate ratios were pooled using the Mantel–Haenszel method and inverse variance method.
  • Heterogeneity of findings was assessed using I2.
  • Subgroup analyses compared SSRIs to non-SSRIs.
  • No significant association between antidepressant use and skin cancer risk was identified.
  • The relative risk (RR) was 0.83 with a confidence interval (CI) of 0.60–1.16.
  • The odds ratio (OR) was 0.93 with a CI of 0.85–1.02.
  • Subgroup analysis findings for SSRI users showed no significant differences.
  • Certainty of evidence was rated very low, necessitating further research.

Cite This Study

Rahman et al. (2026) studied this question.

synapsesocial.com/papers/69e4745f010ef96374d90248https://doi.org/10.1093/skinhd/vzag028
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