What are the clinical and aetiopathogenetic predictors of death or transplantation in patients with biopsy-proven myocarditis?
Biventricular dysfunction and viral genome presence are important prognostic markers for death or transplantation in patients with biopsy-proven myocarditis.
In myocarditis, biventricular dysfunction at diagnosis was the main predictor of death/transplantation. AHA identified immune-mediated myocarditis in the majority of cases. Viral genome was a univariate predictor of adverse prognosis. Our approach of using AHA and positive PCR as aetiopathogenetic markers should help patient selection and recruitment in future studies on aetiological therapy.
Caforio et al. (2007) studied this question.